MGF 2mg – Mechano Growth Factor | Premium Research Grade
IGF-1 Splice Variant | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
MGF (Mechano Growth Factor) is a splice variant of Insulin-Like Growth Factor-1 (IGF-1), produced naturally in response to mechanical stress or tissue damage. This 2mg research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating IGF-1 pathway biology, growth-factor receptor interactions, and cellular proliferation signalling.
Unlike standard IGF-1, MGF contains a unique E-domain peptide sequence at its C-terminus that confers distinct receptor binding characteristics and biological activity. This structural difference makes MGF a valuable standalone research tool for scientists seeking to isolate the specific contributions of this IGF-1 splice variant to growth-factor signalling cascades — separate from the effects of full-length IGF-1.
What is MGF and Why is it Researched?
MGF is generated through alternative splicing of the IGF-1 gene, primarily in response to mechanical loading or cellular stress signals. In research settings, it is studied for its role in activating satellite cells and stimulating cellular proliferation pathways that are distinct from those activated by systemic IGF-1.
Its unique E-domain peptide has been the subject of significant research interest for its ability to interact directly with cellular receptors independently of the IGF-1 receptor, opening avenues for investigating novel growth-factor signalling mechanisms in muscle, bone, and connective tissue research models.
Mechanism of Action
MGF operates through a dual mechanism that distinguishes it from other IGF-1 variants:
IGF-1 Receptor Interaction — The mature IGF-1 domain of MGF activates the IGF-1 receptor (IGF-1R), triggering downstream PI3K/Akt and MAPK/ERK signalling pathways commonly studied in cellular growth and survival research.
E-Domain Activity — MGF’s unique C-terminal E-domain peptide exhibits receptor interactions independent of IGF-1R activation. Research suggests this domain plays a role in activating quiescent stem cells and initiating early-stage cellular repair signalling — a mechanism not observed with standard IGF-1 or its LR3 variant.
Growth-Factor Cascade Initiation — MGF is studied for its role in initiating growth-factor cascades involved in cellular proliferation, differentiation, and tissue response signalling, making it a key compound in regenerative biology research.
Research Applications
MGF 2mg is suited for laboratory investigations including:
- IGF-1 splice variant biology and receptor binding studies
- Cellular proliferation and differentiation pathway research
- Growth-factor cascade mapping and signal transduction analysis
- Satellite cell activation and stem cell response studies
- Protein synthesis pathway investigations
- Comparative studies with other growth-factor peptides in our growth hormone & muscle category
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | IGF-1 splice variant (Mechano Growth Factor) |
| Quantity | 2mg per vial |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Growth hormone & muscle research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized MGF at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — MGF 2mg
What is MGF and how does it differ from IGF-1? MGF is a splice variant of IGF-1 produced in response to mechanical stress or tissue damage. While it shares the IGF-1 receptor-binding domain, its unique C-terminal E-domain peptide gives it distinct biological activity not observed with standard IGF-1 — making it a valuable separate research compound for growth-factor pathway studies.
What does the 2mg quantity refer to? Each vial contains 2mg of lyophilized MGF peptide. This is the standard research quantity supplied by Graded Peptides for laboratory use.
What research areas is MGF most commonly used in? MGF is most commonly studied in the context of IGF-1 pathway biology, cellular proliferation signalling, satellite cell activation, and growth-factor receptor interaction research. It is frequently used alongside other compounds in our growth hormone & muscle peptides category.
What purity level is your MGF? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should MGF be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture and store in a sealed vial until reconstitution.
Do you offer bulk pricing on MGF? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
Reviews
There are no reviews yet.