Semax 30mg – Premium Research Grade
Synthetic ACTH Analog | Neuropeptide CNS Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) 4-7 fragment, developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. This 30mg research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating neurotrophic signalling, BDNF and NGF expression pathways, cognitive function mechanisms, and central nervous system neuropeptide activity in controlled experimental models.
Semax’s peptide sequence — Met-Glu-His-Phe-Pro-Gly-Pro — retains the core receptor-binding region of ACTH while adding a C-terminal Pro-Gly-Pro stabilising sequence that significantly extends its activity compared to native ACTH 4-7. This engineered stability, combined with its ability to cross the blood-brain barrier, makes Semax one of the most practical and widely studied synthetic neuropeptides for CNS research applications.
What is Semax and Why is it Researched?
Semax was originally developed as a research tool for investigating ACTH-related neuropeptide activity in the central nervous system. Unlike full-length ACTH, which exerts broad hormonal effects across multiple organ systems, Semax’s truncated structure focuses its activity on CNS receptor interactions — particularly those influencing neurotrophic factor expression and cognitive signalling pathways.
Research interest in Semax centres primarily on its ability to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in CNS tissue models. BDNF and NGF are critical regulators of neuronal survival, synaptic plasticity, and cognitive function — placing Semax at the forefront of neuropeptide research focused on neurotrophic signalling mechanisms. Compared to its sister compound Selank, Semax has a stronger focus on neurotrophic factor expression while Selank centres more on GABAergic and anxiolytic pathway modulation.
Mechanism of Action
Semax exerts its CNS research-relevant activity through several interconnected neurochemical pathways:
BDNF & NGF Expression Upregulation — Semax’s most extensively studied mechanism is its ability to increase BDNF and NGF expression in hippocampal and cortical tissue research models. BDNF plays a central role in long-term potentiation, synaptic plasticity, and neuronal survival — making Semax a key compound for researchers studying neurotrophic signalling and its relationship to cognitive function mechanisms.
Melanocortin Receptor Interaction — As an ACTH 4-7 analog, Semax interacts with melanocortin receptors expressed in the CNS, particularly MC4R. This receptor interaction is studied for its downstream effects on dopaminergic and serotonergic neurotransmitter systems — pathways relevant to cognitive signalling and stress-response research.
Dopaminergic & Serotonergic Pathway Modulation — Research models have documented Semax’s influence on dopamine and serotonin metabolism in CNS tissue, offering investigators a tool for studying how neuropeptide signals modulate monoamine neurotransmitter systems — a key area of neuropsychopharmacology research.
Stress-Response Pathway Research — Semax’s ACTH-derived structure gives it relevance in HPA axis and stress-response research. Studies have investigated how Semax interacts with stress-signalling pathways in CNS models, providing a research tool for studying neuropeptide-mediated stress modulation mechanisms.
Research Applications
Semax 30mg is suited for laboratory investigations including:
- BDNF and NGF expression pathway studies in CNS tissue models
- Melanocortin receptor pharmacology and ACTH analog research
- Cognitive signalling and synaptic plasticity mechanism investigations
- Dopaminergic and serotonergic neurotransmitter modulation research
- HPA axis and stress-response neuropeptide pathway studies
- Blood-brain barrier peptide transport and CNS bioavailability research
- Comparative neuropeptide studies alongside Selank and DSIP in our cognitive peptides category
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Synthetic ACTH 4-7 analog (heptapeptide) |
| Quantity | 30mg per vial |
| Amino Acid Length | 7 amino acids |
| Origin | Synthetic ACTH fragment derivative |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Cognitive & sleep research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized Semax at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — Semax 30mg
What is Semax used for in research? Semax is used in laboratory research to investigate BDNF and NGF expression pathways, melanocortin receptor pharmacology, cognitive signalling mechanisms, dopaminergic and serotonergic neurotransmitter modulation, and stress-response neuropeptide pathway analysis. It is one of the most studied synthetic neuropeptides for CNS-focused research.
How is Semax related to ACTH? Semax is derived from the ACTH 4-7 fragment — a four-amino acid sequence within adrenocorticotropic hormone responsible for its CNS receptor interactions. The addition of a Pro-Gly-Pro stabilising sequence extends Semax’s biological activity compared to native ACTH 4-7, while its truncated structure removes the broad hormonal effects of full-length ACTH.
How does Semax differ from Selank? Both Semax and Selank are synthetic neuropeptides developed for CNS research, but with distinct mechanisms. Semax is an ACTH analog primarily studied for BDNF/NGF expression upregulation and melanocortin receptor interactions. Selank is a tuftsin analog focused on GABAergic modulation and neuroimmune crosstalk. Researchers frequently use both comparatively in cognitive and stress-response pathway studies.
What does the 30mg quantity refer to? Each vial contains 30mg of lyophilized Semax peptide — a larger research quantity designed to support extended experimental protocols within a single laboratory supply.
What purity level is your Semax? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should Semax be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture and store in a sealed vial until reconstitution.
Do you offer bulk pricing on Semax? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
Reviews
There are no reviews yet.