DSIP 5mg (Delta Sleep-Inducing Peptide) – Premium Research Grade
Neuropeptide | Neuroendocrine & Circadian Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (9 amino acids) first isolated from rabbit cerebral venous blood in 1974. This 5mg research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating sleep-related neuroendocrine signalling, circadian rhythm regulation, stress-response pathways, and central nervous system peptide activity.
DSIP’s unique ability to cross the blood-brain barrier and interact with multiple neuroendocrine systems makes it one of the more versatile neuropeptides available for CNS-focused research. Its interactions span sleep architecture, hormonal regulation, and stress-response modulation — placing it at the intersection of neuroscience, endocrinology, and chronobiology research.
What is DSIP and Why is it Researched?
DSIP was originally identified for its ability to induce delta-wave sleep activity in rabbits when infused into the cerebral ventricles. Since its discovery, research interest has expanded significantly beyond sleep induction to encompass a broader neuroendocrine regulatory role.
DSIP has been studied for interactions with multiple hormonal axes including the hypothalamic-pituitary-adrenal (HPA) axis and growth hormone secretion pathways. Its presence in peripheral tissues including the hypothalamus, pituitary, pancreas, and gut suggests a wide-ranging modulatory role in neuroendocrine communication — making it a compound of interest across multiple research disciplines.
Mechanism of Action
DSIP’s biological activity involves multiple neuroendocrine signalling pathways:
Sleep & Circadian Rhythm Modulation — DSIP was named for its originally observed ability to promote delta-wave sleep states. Researchers investigate its interactions with circadian timing systems and sleep architecture regulatory mechanisms, including its relationship with melatonin secretion and hypothalamic sleep-wake signalling.
HPA Axis Interaction — DSIP has been studied for its modulatory effects on the hypothalamic-pituitary-adrenal axis, particularly in the context of stress-response signalling. Research models use DSIP to investigate how neuropeptides influence cortisol secretion pathways and adrenal stress responses.
Growth Hormone Pathway Research — DSIP has been observed to interact with growth hormone secretion patterns in research models, with studies suggesting both stimulatory and inhibitory effects depending on experimental conditions — making it a compound of interest for researchers studying neuroendocrine control of GH release.
Neurotransmitter Interaction — DSIP interacts with multiple neurotransmitter systems including opioid, serotonergic, and GABAergic pathways, offering researchers a multifaceted tool for studying neuropeptide-neurotransmitter crosstalk in CNS research models.
Research Applications
DSIP 5mg is suited for laboratory investigations including:
- Sleep architecture and delta-wave activity pathway studies
- Circadian rhythm regulation and chronobiology research
- HPA axis signalling and stress-response pathway analysis
- Growth hormone secretion and neuroendocrine control studies
- Neurotransmitter interaction and CNS peptide activity research
- Blood-brain barrier peptide transport investigations
- Comparative studies with other compounds in our cognitive peptides category
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Nonapeptide neuropeptide |
| Quantity | 5mg per vial |
| Amino Acid Length | 9 amino acids |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Cognitive & sleep research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized DSIP at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — DSIP 5mg
What is DSIP used for in research? DSIP is used in laboratory research to investigate sleep-related neuroendocrine signalling, circadian rhythm regulation, HPA axis stress-response pathways, growth hormone secretion modulation, and neurotransmitter interaction. It is a versatile neuropeptide compound suited for CNS, endocrinology, and chronobiology research.
Why is DSIP called the Delta Sleep-Inducing Peptide? DSIP was named after its originally observed effect of inducing delta-wave sleep activity in rabbits when administered intracerebroventricularly. Delta waves are the slow-wave brain oscillations associated with deep sleep stages. Subsequent research has revealed a much broader neuroendocrine regulatory role beyond sleep induction alone.
Can DSIP cross the blood-brain barrier? Research indicates that DSIP can cross the blood-brain barrier, which is a notable characteristic for a peptide compound and contributes to its relevance in CNS-focused research models. This property makes it a useful tool for studying central neuroendocrine signalling pathways.
What does the 5mg quantity refer to? Each vial contains 5mg of lyophilized DSIP peptide — a standard research quantity designed to support multiple experimental runs within a single laboratory supply.
What purity level is your DSIP? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should DSIP be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture and store in a sealed vial until reconstitution.
Do you offer bulk pricing on DSIP? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
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