Kisspeptin-10 10mg – Premium Research Grade
Decapeptide HPG Axis Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
Kisspeptin-10 is a synthetic decapeptide representing the active C-terminal fragment of the kisspeptin peptide family, encoded by the KISS1 gene. This 10mg research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating hypothalamic-pituitary-gonadal (HPG) axis signalling, gonadotropin-releasing hormone (GnRH) pathway activation, and reproductive endocrinology.
As the minimal active fragment of kisspeptin capable of full KISS1R (GPR54) receptor activation, Kisspeptin-10 is the most widely used kisspeptin variant in research settings. Its compact decapeptide structure — comprising the final 10 amino acids of the kisspeptin sequence — retains full biological activity at the receptor level while offering improved handling characteristics compared to longer kisspeptin variants like Kisspeptin-54.
What is Kisspeptin-10 and Why is it Researched?
Kisspeptin peptides are endogenous neuropeptides produced primarily in the hypothalamus, where they act as master regulators of the reproductive endocrine axis. By activating KISS1R receptors on GnRH-secreting neurons, kisspeptin signalling directly controls the pulsatile release of GnRH — the upstream regulator of LH (luteinizing hormone) and FSH (follicle-stimulating hormone) secretion from the pituitary gland.
Kisspeptin-10 is the research standard for studying this regulatory axis, providing scientists with a defined, stable, and potent tool for probing HPG axis signalling from its most upstream point. Its role as a gatekeeper of reproductive hormone cascades makes it one of the most important compounds in neuroendocrine research.
Mechanism of Action
Kisspeptin-10 acts through highly specific receptor binding and downstream neuroendocrine signalling:
KISS1R (GPR54) Activation — Kisspeptin-10 binds with high affinity to the KISS1R receptor, a Gq-coupled receptor expressed on GnRH neurons in the hypothalamus. Receptor activation triggers intracellular calcium mobilisation and downstream signalling cascades that stimulate GnRH neuron firing.
GnRH Pulse Regulation — Through KISS1R activation, Kisspeptin-10 regulates the pulsatile secretion of GnRH — the central signal governing reproductive hormone release. Researchers use Kisspeptin-10 to study how upstream neuroendocrine signals control downstream LH and FSH secretion patterns.
HPG Axis Modulation — As a key regulator of the hypothalamic-pituitary-gonadal axis, Kisspeptin-10 enables researchers to investigate how central neuroendocrine signals translate into peripheral reproductive hormone responses — a critical area of study in reproductive biology and endocrinology research.
Research Applications
Kisspeptin-10 10mg is suited for laboratory investigations including:
- HPG axis signalling and GnRH pathway studies
- KISS1R receptor binding affinity and pharmacology research
- Neuroendocrine signal cascade mapping
- Reproductive hormone regulation and LH/FSH secretion studies
- Puberty-related signalling and developmental endocrinology research
- Peptide stability and degradation analysis in biological models
- Comparative studies with other compounds in our sexual health & wellness category
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Kisspeptin active fragment (decapeptide) |
| Quantity | 10mg per vial |
| Amino Acid Length | 10 amino acids |
| Target Receptor | KISS1R (GPR54) |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Sexual health & wellness research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized Kisspeptin-10 at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — Kisspeptin-10
What is Kisspeptin-10 used for in research? Kisspeptin-10 is used in laboratory research to investigate HPG axis signalling, GnRH pathway activation, KISS1R receptor pharmacology, reproductive hormone regulation, and neuroendocrine cascade mapping. It is the primary research tool for studying upstream control of the reproductive endocrine axis.
What is the difference between Kisspeptin-10 and Kisspeptin-54? Kisspeptin-54 is the full-length kisspeptin peptide, while Kisspeptin-10 is its minimal active C-terminal fragment. Kisspeptin-10 retains full KISS1R receptor activation capability and is the most commonly used variant in research due to its defined structure, easier synthesis, and comparable biological activity at the receptor level.
What does the 10mg quantity refer to? Each vial contains 10mg of lyophilized Kisspeptin-10 peptide — a standard research quantity designed to support multiple experimental runs within a single laboratory supply.
What purity level is your Kisspeptin-10? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should Kisspeptin-10 be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture and store in a sealed vial until reconstitution.
Do you offer bulk pricing on Kisspeptin-10? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
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