Adipotide 10mg – Premium Research Grade
Proapoptotic Peptidomimetic | Adipose Vasculature Targeting Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
Adipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) is a synthetic proapoptotic peptidomimetic designed to selectively target vasculature associated with white adipose tissue. This 10mg research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating adipose tissue vascular targeting mechanisms, receptor-mediated cellular apoptosis pathways, prohibitin-directed peptide binding, and adipose tissue biology in controlled experimental models.
Adipotide’s unique bipartite structure — combining a targeting peptide sequence that binds prohibitin on adipose vascular endothelium with a proapoptotic peptide domain — makes it one of the most mechanistically distinct compounds in metabolic research. Its highly specific adipose tissue targeting profile, achieved through prohibitin receptor engagement rather than systemic metabolic pathway modulation, distinguishes it from GLP-1 based metabolic research compounds and represents a fundamentally different approach to studying adipose tissue biology.
What is Adipotide and Why is it Researched?
Adipotide was developed by researchers at MD Anderson Cancer Center as part of a broader programme investigating targeted proapoptotic peptidomimetics — compounds designed to deliver cell death signals specifically to vascular cells supplying defined tissue types. The strategy exploits differential protein expression patterns on vascular endothelium to achieve tissue-selective targeting.
In Adipotide’s case, the targeting domain binds prohibitin — a protein found at elevated levels on the vascular endothelium of white adipose tissue but not on most other vascular beds. This selectivity enables researchers to study what happens to adipose tissue when its dedicated blood supply is specifically disrupted, making Adipotide a unique tool for investigating adipose tissue vascular dependency, cellular apoptosis signalling, and the relationship between adipose vasculature and tissue mass regulation.
Mechanism of Action
Adipotide operates through a highly specific two-domain targeting and effector mechanism:
Prohibitin-Directed Vascular Targeting — The CKGGRAKDC targeting domain of Adipotide binds selectively to prohibitin expressed on the luminal surface of white adipose tissue vascular endothelium. Prohibitin’s differential expression on adipose versus non-adipose vasculature provides the tissue selectivity that makes Adipotide a unique research tool for studying adipose vascular biology.
Proapoptotic Domain Activity — Once bound to adipose vascular endothelium via prohibitin engagement, the D(KLAKLAK)₂ proapoptotic domain disrupts mitochondrial membrane integrity in targeted cells, initiating the intrinsic apoptosis pathway. Researchers use this mechanism to study how targeted endothelial apoptosis affects adipose tissue vascular architecture and tissue mass in experimental models.
Adipose Tissue Vascular Dependency Research — By selectively disrupting adipose tissue vasculature, Adipotide enables researchers to investigate the degree to which white adipose tissue mass depends on continuous vascular support — providing insights into adipose tissue biology that complement findings from metabolic pathway research using GLP-1 compounds like Semaglutide and Tirzepatide.
Cellular Apoptosis Pathway Analysis — Adipotide’s proapoptotic mechanism provides a controlled model for studying mitochondrial apoptosis pathway activation in vascular endothelial cells, making it relevant for researchers investigating apoptosis signalling mechanisms beyond its adipose tissue targeting application.
Research Applications
Adipotide 10mg is suited for laboratory investigations including:
- Prohibitin receptor binding and adipose vascular endothelium targeting studies
- Proapoptotic peptidomimetic mechanism and mitochondrial apoptosis pathway research
- White adipose tissue vascular architecture and dependency investigations
- Targeted peptide delivery mechanism and tissue selectivity research
- Comparative metabolic research alongside GLP-1 compounds in our GLP-1 & weight loss category
- Adipose tissue biology and cellular apoptosis signalling studies
- Vascular targeting peptidomimetic pharmacology research
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Proapoptotic bipartite peptidomimetic |
| Full Structure | CKGGRAKDC-GG-D(KLAKLAK)₂ |
| Quantity | 10mg per vial |
| Target | Prohibitin on adipose vascular endothelium |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | GLP-1 & weight loss research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized Adipotide at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — Adipotide 10mg
What is Adipotide used for in research? Adipotide is used in laboratory research to investigate prohibitin-directed vascular targeting mechanisms, proapoptotic peptidomimetic activity, white adipose tissue vascular dependency, mitochondrial apoptosis pathway activation in endothelial cells, and adipose tissue biology. It represents a mechanistically distinct approach to adipose tissue research compared to metabolic pathway compounds.
What is prohibitin and why is it important for Adipotide research? Prohibitin is a multifunctional protein found at elevated levels on the luminal surface of white adipose tissue vascular endothelium. Its differential expression compared to non-adipose vasculature is what gives Adipotide its tissue-selective targeting capability. Researchers study prohibitin as a vascular marker and targeting receptor in adipose tissue biology investigations.
How does Adipotide differ from GLP-1 metabolic research compounds? GLP-1 compounds like Semaglutide and Tirzepatide modulate metabolic hormone pathways to study energy homeostasis and glucose regulation. Adipotide takes a fundamentally different approach — targeting the vasculature that supplies adipose tissue directly through prohibitin binding and proapoptotic signalling. The two compound classes are often used complementarily in metabolic research programmes.
What does the 10mg quantity refer to? Each vial contains 10mg of lyophilized Adipotide — a standard research quantity designed to support multiple experimental protocols within a single laboratory supply.
What purity level is your Adipotide? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
Do you offer bulk pricing on Adipotide? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
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