Follistatin-344 – Premium Research Grade
Myostatin Antagonist | Muscle & Regenerative Biology Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
Follistatin-344 is a 344-amino acid isoform of follistatin — a naturally occurring glycoprotein and potent antagonist of myostatin (GDF-8) and activin signalling. This research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating myostatin inhibition pathways, muscle cell growth signalling, TGF-β superfamily receptor interactions, and regenerative biology mechanisms in controlled experimental models.
As the predominant follistatin isoform found in muscle tissue, Follistatin-344 is the most relevant variant for musculoskeletal research. Its core mechanism — binding and neutralising myostatin, the primary negative regulator of skeletal muscle mass — places it at the centre of muscle biology research and makes it one of the most studied proteins in the growth hormone and muscle peptide research category.
What is Follistatin-344 and Why is it Researched?
Follistatin was first identified as a follicle-stimulating hormone (FSH)-suppressing protein isolated from ovarian follicular fluid. Subsequent research revealed its far broader biological role as a high-affinity binding protein capable of neutralising multiple members of the TGF-β superfamily — most notably myostatin and activin A.
Myostatin is a potent negative regulator of skeletal muscle mass, acting through ActRIIB receptor signalling to suppress muscle protein synthesis and promote muscle protein degradation. By binding myostatin with high affinity, Follistatin-344 effectively removes this inhibitory brake on muscle growth signalling — making it a central research tool for scientists studying how myostatin pathway modulation influences skeletal muscle biology, satellite cell activation, and regenerative tissue responses.
Mechanism of Action
Follistatin-344 exerts its research-relevant biological activity through direct ligand binding and downstream pathway modulation:
Myostatin (GDF-8) Neutralisation — Follistatin-344 binds myostatin with high affinity, preventing it from engaging ActRIIB (Activin Receptor Type IIB) on muscle cell surfaces. By blocking myostatin-receptor interaction, Follistatin-344 removes the primary negative regulatory signal limiting muscle protein synthesis — a mechanism central to muscle hypertrophy pathway research.
Activin A Antagonism — Beyond myostatin, Follistatin-344 binds and neutralises activin A — another TGF-β superfamily member that suppresses muscle growth and influences reproductive hormone signalling. This dual antagonism makes Follistatin-344 relevant for researchers studying both musculoskeletal and endocrine pathway interactions.
Satellite Cell & Regenerative Pathway Research — Myostatin signalling suppresses satellite cell (muscle stem cell) activation and proliferation. Follistatin-344’s myostatin antagonism in research models allows scientists to investigate how satellite cell activation and muscle regeneration signalling respond when myostatin inhibition is introduced — a key area of regenerative biology research.
TGF-β Superfamily Pathway Modulation — As a broad TGF-β superfamily antagonist, Follistatin-344 enables researchers to investigate how multiple growth factor signalling pathways interact in muscle, bone, and reproductive tissue research models.
Research Applications
Follistatin-344 is suited for laboratory investigations including:
- Myostatin inhibition mechanism and ActRIIB pathway studies
- Skeletal muscle growth signalling and hypertrophy pathway research
- Satellite cell activation and muscle regeneration biology
- TGF-β superfamily ligand-receptor interaction studies
- Activin A antagonism and endocrine pathway research
- Comparative studies with other compounds in our growth hormone & muscle peptides category
- Tissue repair and regenerative signalling pathway investigations
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Follistatin isoform (myostatin antagonist) |
| Isoform | Follistatin-344 (344 amino acids) |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Growth hormone & muscle research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized Follistatin-344 at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Due to its larger molecular size, Follistatin-344 requires careful, gentle reconstitution — add bacteriostatic water slowly to the side of the vial and allow to dissolve without agitation. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — Follistatin-344
What is Follistatin-344 used for in research? Follistatin-344 is used in laboratory research to investigate myostatin inhibition pathways, skeletal muscle growth signalling, satellite cell activation, TGF-β superfamily receptor interactions, and regenerative biology mechanisms. It is the primary research compound for studying how myostatin pathway modulation influences muscle biology.
What is myostatin and why is it important in muscle research? Myostatin (GDF-8) is a TGF-β superfamily protein that acts as the primary negative regulator of skeletal muscle mass. It signals through ActRIIB receptors to suppress muscle protein synthesis and inhibit satellite cell activation. Studying myostatin inhibition — using compounds like Follistatin-344 — is central to understanding the molecular regulation of muscle growth and regeneration.
What is the difference between Follistatin-344 and Follistatin-315? Follistatin exists in multiple isoforms. Follistatin-344 is the predominant isoform found in muscle tissue and has a heparan sulfate-binding domain that anchors it to cell surfaces — making it particularly relevant for muscle biology research. Follistatin-315 lacks this domain, resulting in different tissue distribution and receptor interaction characteristics suited to different research applications.
What purity level is your Follistatin-344? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should Follistatin-344 be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture. Reconstitute gently with bacteriostatic water without agitation due to the protein’s larger molecular size.
Do you offer bulk pricing on Follistatin-344? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
Reviews
There are no reviews yet.