CJC-1295 Without DAC – Premium Research Grade
Synthetic GHRH Analog | Pulsatile Growth Hormone Research Compound | ≥99% Purity | HPLC-Tested | Lyophilized Powder
Product Overview
CJC-1295 without DAC is a synthetic 30-amino acid analog of Growth Hormone Releasing Hormone (GHRH), engineered to bind selectively to GHRH receptors on pituitary somatotroph cells and stimulate endogenous, pulsatile growth hormone secretion. This research-grade formulation provides laboratories with a high-purity, HPLC-verified compound for investigating GH axis pharmacology, IGF-1 signalling pathways, pulsatile hormone secretion mechanisms, and downstream metabolic and anabolic signalling responses in controlled experimental models.
The defining characteristic of CJC-1295 without DAC — compared to its DAC-modified counterpart — is its preservation of physiological GH release patterns. By maintaining a shorter activity profile that mirrors natural GHRH pulse dynamics, CJC-1295 without DAC allows researchers to study pulsatile GH secretion under conditions that closely replicate endogenous hormonal rhythms. This makes it a distinctly different research tool from DAC-modified versions, which produce prolonged, non-pulsatile GH elevation more suited to sustained GH axis saturation studies.
What is CJC-1295 Without DAC and Why is it Researched?
GHRH is the primary hypothalamic signal driving growth hormone release from the pituitary gland. It acts through GHRH receptors (GHRHR) on somatotroph cells to stimulate GH synthesis and secretion in discrete pulses — a rhythm critical to the downstream biological effects of GH signalling. Native GHRH has an extremely short half-life of 2–3 minutes due to rapid enzymatic degradation, making it impractical as a sustained research tool.
CJC-1295 without DAC addresses this limitation through targeted amino acid substitutions that confer resistance to enzymatic degradation while preserving GHRHR binding affinity and pulsatile activity dynamics. With a half-life of approximately 30 minutes, it provides a practical research window for studying GHRH receptor pharmacology and pulsatile GH secretion without the sustained, non-physiological GH elevation produced by DAC-modified analogs — making it the preferred compound for researchers studying natural GH rhythm biology.
Mechanism of Action
CJC-1295 without DAC stimulates the GH axis through direct receptor engagement and downstream signalling cascade activation:
GHRH Receptor (GHRHR) Activation — CJC-1295 without DAC binds selectively to GHRHR on anterior pituitary somatotroph cells, activating adenylyl cyclase through Gs protein coupling. The resulting increase in intracellular cAMP activates PKA signalling, stimulating GH synthesis and secretion in a pulse pattern that mirrors physiological GHRH dynamics.
Pulsatile GH Secretion Research — A key research distinction of CJC-1295 without DAC is its preservation of pulsatile GH release. Researchers use it to study how pulsatile versus sustained GH exposure differentially affects downstream IGF-1 signalling, receptor sensitivity, and anabolic pathway responses — a critical area for understanding GH axis biology.
IGF-1 Pathway Stimulation — GH secretion stimulated by CJC-1295 without DAC drives hepatic IGF-1 production through GH receptor activation in liver tissue. Researchers investigate the downstream IGF-1 signalling cascade — including PI3K/Akt and MAPK/ERK pathway activation — in the context of pulsatile versus sustained GH stimulation models.
Metabolic & Anabolic Pathway Research — GH and IGF-1 signalling influence protein synthesis, lipid metabolism, glucose homeostasis, and bone metabolism. CJC-1295 without DAC enables researchers to study these downstream metabolic and anabolic pathway responses in the context of physiologically relevant pulsatile GH stimulation.
CJC-1295 Without DAC vs With DAC — Research Distinction
| Property | CJC-1295 Without DAC | CJC-1295 With DAC |
|---|---|---|
| Half-life | ~30 minutes | ~6–8 days |
| GH release pattern | Pulsatile (physiological) | Sustained (non-pulsatile) |
| Research application | Pulsatile GH rhythm studies | Sustained GH elevation studies |
| GHRHR binding | Direct, time-limited | Albumin-extended |
Research Applications
CJC-1295 without DAC is suited for laboratory investigations including:
- GHRH receptor pharmacology and pituitary somatotroph signalling research
- Pulsatile GH secretion mechanism and rhythm biology studies
- IGF-1 pathway stimulation and downstream signalling cascade investigations
- Comparative pulsatile vs sustained GH exposure research alongside DAC-modified analogs
- Protein synthesis, muscle biology, and anabolic pathway studies
- Lipid metabolism and energy regulation pathway research
- Bone metabolism and collagen synthesis signalling investigations
- Comparative studies with other compounds in our growth hormone & muscle peptides category including GHRP-6 and Follistatin-344
Product Specifications
| Property | Detail |
|---|---|
| Peptide Type | Synthetic GHRH analog (no DAC modification) |
| Amino Acid Length | 30 amino acids |
| Half-Life | ~30 minutes |
| GH Release Pattern | Pulsatile |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Category | Growth hormone & muscle research |
| Storage | -20°C long-term, 4°C short-term |
Storage & Reconstitution
Store lyophilized CJC-1295 without DAC at -20°C for long-term stability or at 4°C for use within 4–6 weeks. Protect from light and moisture at all times and keep vials tightly sealed until ready for use. Reconstitute with bacteriostatic water under sterile laboratory conditions. All reconstitution supplies are available in our accessories category.
Frequently Asked Questions — CJC-1295 Without DAC
What is CJC-1295 without DAC used for in research? CJC-1295 without DAC is used in laboratory research to investigate GHRH receptor pharmacology, pulsatile GH secretion mechanisms, IGF-1 signalling pathways, and downstream metabolic and anabolic responses to physiological GH stimulation. Its preservation of natural pulsatile GH rhythm makes it the preferred compound for studies examining GH axis biology under physiologically relevant conditions.
What does “without DAC” mean? DAC (Drug Affinity Complex) is a modification added to some CJC-1295 formulations that enables albumin binding, extending half-life to 6–8 days and producing sustained, non-pulsatile GH elevation. CJC-1295 without DAC lacks this modification, resulting in a ~30-minute half-life and pulsatile GH release that mirrors natural GHRH dynamics — a critical distinction for research design.
How does CJC-1295 without DAC compare to GHRP-6? CJC-1295 without DAC is a GHRH analog that stimulates GH release through GHRHR activation. GHRP-6 is a ghrelin receptor (GHS-R1a) agonist that stimulates GH release through a distinct receptor pathway. Researchers frequently use both compounds together to study synergistic GH axis stimulation through complementary receptor mechanisms.
What is the relationship between CJC-1295 without DAC and IGF-1? CJC-1295 without DAC stimulates pituitary GH secretion, which drives hepatic IGF-1 production through GH receptor activation. Researchers studying IGF-1 pathway biology use CJC-1295 without DAC as an upstream stimulant to investigate how pulsatile GH signals translate into IGF-1 expression and downstream anabolic pathway activation.
What purity level is your CJC-1295 without DAC? Every batch is HPLC-tested to ≥99% purity. Certificates of Analysis are available on request for all orders.
How should CJC-1295 without DAC be stored? Store at -20°C for long-term use or at 4°C for short-term use within 4–6 weeks. Keep away from light and moisture and store in a sealed vial until reconstitution.
Do you offer bulk pricing on CJC-1295 without DAC? Yes. Bulk discounts are available for research institutions and laboratories. Contact us directly for volume pricing details.
For research and laboratory use only. Not intended for human or veterinary consumption. Not for use in the diagnosis, treatment, cure, or prevention of any disease.
Reviews
There are no reviews yet.